Whilst working on visualisations for my WordSquares project, I encountered problems due to the size of the dataset I wanted to plot. Digging into the Bokeh library I found out about the Datashader library that specialises in large datasets (e.g. billions of points).
For further reference, an introduction to Bokeh:
As well as another presentation including various libraries, Bokeh, Datashader, and others, to deal with large dataset representations:
Another tool that could prove useful for working with multidimensional labelled datasets (used in the introduction to Datashader above), where Pandas only work for higher dimensions: